Cortisone has powerful anti-inflammatory properties. It cannot relieve pain directly and only treats inflammation. So, steroid injections also contain an anesthetic for pain relief. When the pain eventually decreases, it is because the inflammation has reduced. The time taken to get relief varies between individuals. You will probably see relief from pain in 48 hours or 72 hours. If there is severe inflammation, or if the inflammation is chronic, the cortisone may take a little more time to give relief and the individual may have to get multiple injections. Most people with joint inflammation will benefit from cortisone injections.