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  Product Name:LGD3303
  • CAS:1196133-39-7
  • FM:C16H14ClF3N2O2
  • MW:342.74300
  • Purity: 99%
  •  
    1. The introduction of LDG-3303 Physical and chemical parameters 2. LDG-3303 effect and application prospects 3. LDG-3303 Working principle and clinical research 4. LDG-3303 Dosage(for your reference only) 5. How to buy LDG-3303 and what is the price? 6. The introduction of LDG-3303 delivery methods 7. Reliable LDG-3303 powder manufacturer(About our factory)
    1. The introduction of LDG-3303 Physical and chemical parameters
    Product Name LGD-3303
    CAS No 1196133-39-7
    Formule C16H14ClF3N2O
    Weight 342.74300
    Storage conditions 2-8°C
    Purity 99%
    Physical state powder
    Packing Bagged
    Supply 50kg
    Place of Origin China

    Product Name LGD-3303
    CAS No 1196133-39-7
    Formule C16H14ClF3N2O
    Weight 342.74300
    Storage conditions 2-8°C
    Purity 99%
    Physical state powder
    Packing Bagged
    Supply 50kg
    Place of Origin China

    2. LDG-3303 effect and application prospects
    As a latest SARM, LGD-3303 has potent activity against the levator ani muscle in a castrated rat model of androgen deficiency, but only partial agonist activity in the foreskin and ventral prostate. Although the plasma concentration of the compound increased, LGD-3303 never stimulated the ventral prostate beyond intact levels. When LGD-3303 was administered orally or by continuous infusion, tissue selective activity was maintained and the time of the two routes of administration was significantly different from the profile of exposure. Although the local tissue concentration of LGD-3303 is higher in the prostate than in the levator muscle, compared to greater muscle activity in the prostate. LGD-3303 has SARM properties that are independent of its pharmacokinetic characteristics, suggesting that the main mechanism of tissue-selective activity is the result of molecular interactions that change at androgen receptor levels.
    Experimental materials and methods:
    The selected compound was LGD-3303. LGD-3303 is a non-steroidal androgen receptor agonist that efficiently binds the androgen receptor and activates gene transcription. LGD-3303 has minimal binding or transcriptional activity on relevant nuclear receptors (Vajda , 2008). LGD-3303 was synthesized at Ligand Pharmaceuticals (San Diego, CA).
     
    3. LDG-3303 Working principle and clinical research
    The pharmacological effects of LGD-3303 in ORDX male rats treated by oral gavage for 14 days. Trend significantly reduced levator ani muscle weight, abdominal prostate weight, and preputial gland weight, but increased serum LH. LGD-3303 inhibited the effect of ORDX on the levator anal weight at doses of 1 mg/kg/day and significantly increased muscle weight over eugonad levels at higher doses. LGD-3303 inhibited serum LH levels against eugonadale. LGD-3303 has a lesser effect on the ventral prostate, maintaining eugonadal levels in the peritoneal prostate at doses of 100 mg/kg/day or higher. Black bar, ORDX control; Solid horizontal line, sham control ¡À SEM (horizontal dotted line). *, p <0.05 compared to ORDX control; +, p < 0.05 compared to sham intact control by one-way ANOVA.
    4. LDG-3303 Dosage(for your reference only)
    LGD-3303 oral and infusion doses. Rats were sorted by weight, assigned to experimental groups (n = 5/group) and operated as described above. The experimental group consisted of oral administration of LGD-3303 (0.3-100 mg/kg/day) or osmotic minipump (Alzet model 2ML1; Alzet, Cupertino, CA; constant infusion of LGD-3303; dose range of 0.01-10 mg/L Kg/day). Small pumps were surgically implanted into intradermal tissue, while rats underwent ORDX under anesthesia. Seven days later, the rats were anesthetized and a small pump was surgically removed and replaced with a new small pump. LGD-3303 was formulated for oral administration as described above and formulated for micropump administration in 50% polyethylene glycol-400:50% dimethylsulfoxide. On the 14th day of the experiment, blood was collected into the lithium heparin tube (Becton Dickinson) by jugular puncture at 0, 0.5, 1, 2, 4, 8, 12 and 24 hours after administration. The blood was centrifuged and the plasma concentration of LGD-3303 was measured. On the fifteenth day, the rats were sacrificed and the wet weights of the ventral prostate and levator ani muscles were measured.
    5. How to buy LDG-3303 and what is the price?
    The methods of buying LDG-3303: You can contact sales customer service staff online through E-mial, WhatsAPP, Skype, etc. We need your help to provide more information like quality,quantity and shipping. Our staff will verify and confirm the purchase qualification with you and they will give you the exact price and freight according to the quantity of your demand and the way of delivery.
    6. The introduction of LDG-3303 delivery methods
    Please provide accurate delivery address to us, our company will choose efficient and safe delivery method according to your delivery quantity and customs situation. We have cooperation with international logistics companies such as FEDEX, DHL, UPS and EMS. For small packages of kilograms or less, it is recommended to use FEDEX, DHL, UPS, EMS and other air express delivery. We have suitable dedicated channels to delivery. It is efficient and safe. For large package shipments, we are working with senior shipping and shipping companies for low cost and high safety. After you confirm the delivery plan, we will ship the goods after receive your payment and provide the tracking number to you. We accept Western Union, MoneyGram, T/T and other payment terms.
    7. Reliable LDG-3303 powder manufacturer(About our factory)
    DMK Biotechnology Co., Ltd specilized in producing Methandrostenolone.Our company has a specialized production base in China, two R & D laboratories and 20 doctorate R & D personnel. Now more than 30 stable production processes have been developed. The products cover  SARMS, nootropics, hormone steroids, API, bioactive molecules and other new compounds. The company adheres to the principle of customer-oriented, quality first. The company strictly controls the quality of each batch of product production and process control processes in accordance with ISO9001, ISO1400 and GMP control standards. In order to guarantee the quality of the products, we carry out the internal inspection and external reinspection of each batch of products. Before shipment, we will provide the products HHMR, HPLC, MS and other related inspection data. DMK Biotechnology Co., Ltd believes that quality is the foundation of the company's life and aims to provide customers with high quality products and services! 
    Product Name:LGD3303
    CAS:1196133-39-7 FM:C16H14ClF3N2O MW:342.74300 Purity: 99%
    • Email:wzh@dmksw.xin
    • Email:gq@dmksw.xin
    • Telephone:8613260607296(SKYPE)
    • Telephone:8618942921723(SKYPE)






    Key words:LGD3303 powder,buy LGD3303,LGD3303 price,LGD3303 Effects,LGD3303 Dosages,mk677 factory,mk677 supplier
    Products introduction:Our company is the largest API manufacturer of LGD3303 in China.Our production of LGD3303 has ahistory of 5 years, and all production LGD3303 raw materials have a purity of more than 99% and each batch has HPLC and NMR detection reports.Our price for LGD3303
    • Products details
    • Products information
    • Buyer Transaction
    1. The introduction of LDG-3303 Physical and chemical parameters
    Product Name LGD-3303
    CAS No 1196133-39-7
    Formule C16H14ClF3N2O
    Weight 342.74300
    Storage conditions 2-8°C
    Purity 99%
    Physical state powder
    Packing Bagged
    Supply 50kg
    Place of Origin China

    2. LDG-3303 effect and application prospects
    As a latest SARM, LGD-3303 has potent activity against the levator ani muscle in a castrated rat model of androgen deficiency, but only partial agonist activity in the foreskin and ventral prostate. Although the plasma concentration of the compound increased, LGD-3303 never stimulated the ventral prostate beyond intact levels. When LGD-3303 was administered orally or by continuous infusion, tissue selective activity was maintained and the time of the two routes of administration was significantly different from the profile of exposure. Although the local tissue concentration of LGD-3303 is higher in the prostate than in the levator muscle, compared to greater muscle activity in the prostate. LGD-3303 has SARM properties that are independent of its pharmacokinetic characteristics, suggesting that the main mechanism of tissue-selective activity is the result of molecular interactions that change at androgen receptor levels.
    Experimental materials and methods:
    The selected compound was LGD-3303. LGD-3303 is a non-steroidal androgen receptor agonist that efficiently binds the androgen receptor and activates gene transcription. LGD-3303 has minimal binding or transcriptional activity on relevant nuclear receptors (Vajda , 2008). LGD-3303 was synthesized at Ligand Pharmaceuticals (San Diego, CA).
     
    3. LDG-3303 Working principle and clinical research
    The pharmacological effects of LGD-3303 in ORDX male rats treated by oral gavage for 14 days. Trend significantly reduced levator ani muscle weight, abdominal prostate weight, and preputial gland weight, but increased serum LH. LGD-3303 inhibited the effect of ORDX on the levator anal weight at doses of 1 mg/kg/day and significantly increased muscle weight over eugonad levels at higher doses. LGD-3303 inhibited serum LH levels against eugonadale. LGD-3303 has a lesser effect on the ventral prostate, maintaining eugonadal levels in the peritoneal prostate at doses of 100 mg/kg/day or higher. Black bar, ORDX control; Solid horizontal line, sham control ¡À SEM (horizontal dotted line). *, p <0.05 compared to ORDX control; +, p < 0.05 compared to sham intact control by one-way ANOVA.
    4. LDG-3303 Dosage(for your reference only)
    LGD-3303 oral and infusion doses. Rats were sorted by weight, assigned to experimental groups (n = 5/group) and operated as described above. The experimental group consisted of oral administration of LGD-3303 (0.3-100 mg/kg/day) or osmotic minipump (Alzet model 2ML1; Alzet, Cupertino, CA; constant infusion of LGD-3303; dose range of 0.01-10 mg/L Kg/day). Small pumps were surgically implanted into intradermal tissue, while rats underwent ORDX under anesthesia. Seven days later, the rats were anesthetized and a small pump was surgically removed and replaced with a new small pump. LGD-3303 was formulated for oral administration as described above and formulated for micropump administration in 50% polyethylene glycol-400:50% dimethylsulfoxide. On the 14th day of the experiment, blood was collected into the lithium heparin tube (Becton Dickinson) by jugular puncture at 0, 0.5, 1, 2, 4, 8, 12 and 24 hours after administration. The blood was centrifuged and the plasma concentration of LGD-3303 was measured. On the fifteenth day, the rats were sacrificed and the wet weights of the ventral prostate and levator ani muscles were measured.
    5. How to buy LDG-3303 and what is the price?
    The methods of buying LDG-3303: You can contact sales customer service staff online through E-mial, WhatsAPP, Skype, etc. We need your help to provide more information like quality,quantity and shipping. Our staff will verify and confirm the purchase qualification with you and they will give you the exact price and freight according to the quantity of your demand and the way of delivery.
    6. The introduction of LDG-3303 delivery methods
    Please provide accurate delivery address to us, our company will choose efficient and safe delivery method according to your delivery quantity and customs situation. We have cooperation with international logistics companies such as FEDEX, DHL, UPS and EMS. For small packages of kilograms or less, it is recommended to use FEDEX, DHL, UPS, EMS and other air express delivery. We have suitable dedicated channels to delivery. It is efficient and safe. For large package shipments, we are working with senior shipping and shipping companies for low cost and high safety. After you confirm the delivery plan, we will ship the goods after receive your payment and provide the tracking number to you. We accept Western Union, MoneyGram, T/T and other payment terms.
    7. Reliable LDG-3303 powder manufacturer(About our factory)
    DMK Biotechnology Co., Ltd specilized in producing Methandrostenolone.Our company has a specialized production base in China, two R & D laboratories and 20 doctorate R & D personnel. Now more than 30 stable production processes have been developed. The products cover  SARMS, nootropics, hormone steroids, API, bioactive molecules and other new compounds. The company adheres to the principle of customer-oriented, quality first. The company strictly controls the quality of each batch of product production and process control processes in accordance with ISO9001, ISO1400 and GMP control standards. In order to guarantee the quality of the products, we carry out the internal inspection and external reinspection of each batch of products. Before shipment, we will provide the products HHMR, HPLC, MS and other related inspection data. DMK Biotechnology Co., Ltd believes that quality is the foundation of the company's life and aims to provide customers with high quality products and services! 
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