2. Sunifiram effect and application prospects
Sunifiram works very similarly to other racetams by stimulating many of the same receptors just in different ways. The primary effect of taking Sunifiram is stimulation of AMPA receptors (hence which this drug is considered an AMPAkine).
In clinical trials, patients given the AMPA antagonist NBQX and then given Sunifiram saw increased AMPA receptor activity. AMPA receptors are responsible for how much glutamate is produced in the brain.
Glutamate is perhaps the most important neurotransmitter in the brain, responsible for communicating excitatory transmissions, forming connections between synapses, and for regulating brain cell survival.
Glutamate is highly involved in brain metabolism as well as synaptic plasticity. Too little glutamate and your cognitive abilities will be greatly impaired, resulting in less attention span, poor ability to learn information and difficulty remembering.
Sunifiram can help reverse this by raising levels of glutamate so your brain performance is increased. Especially when engaging in long periods of mental exertion, you will find that Sunifiram makes it easier to remember information and learn new concepts.
Sunifiram also effects levels of acetylcholine in the brain just like Piracetam, Pramiracetam, Aniracetam, Oxiracetam and other racetam nootropics. Studies have established that taking Sunifiram is Cholinergic meaning that it causes more of this neurotransmitter to be released.
Increased presence of Acetylcholine in the cerebral cortex leads to improved thinking, perception, alertness, learning, memory and focus. Acetycholine makes it easier for your left and right brain hemispheres to communicate as well which can cause you to recognize patterns and connections more effectively as well as improve basic social skills like talking in group settings.