2. Phenibut effect and application prospects
1.Phenibut is a derivative of the naturally occurring inhibitory neurotransmitter GABA.
2.Phenibut is used by bodybuilders to reduce fatigue and improve neurological functions.
3.Phenibut has been and is still used medically to treat stress,relieve tension, improve sleep,and as a potentiate for other medications.
phenibut is a gaba receptor agonist and also causes the release of gaba. similar to baclofen, phenibut is an agonist at gaba(b) receptors, although it does have some effect on gaba(a) receptors as well. it is possible that phenibut has a higher activity at central gaba(b) receptors than peripheral ones. the role of the gaba(b) receptor is not well-established, although research in the last seven years has significantly increased our understanding of this receptor. the most well-established role of gaba(b) receptors is inhibition of the release of some neurotransmitters, and it may also serve as a negative feedback mechanism for gaba release
Because of the structural similarity to pea, phenibut may share some similarities and differences with it. when phenibut is administered along with pea, it antagonizes many of its effects, such as promotion of anxiety, promotion of seizures, and hyperthermia. this has lead some to postulate that antagonism of pea, rather than the gaba-mimetic activity, may be the important mechanism of action for tha anxiolytic effect of phenibut.
Phenibut also increases dopamine levels, and it has been postulated that the structural similarity to pea may play a role in this effect.