5. IDRA-21 side effects and how to cope with them and attention
When used appropriately, it is relatively safe however; be aware that it actually worsens brain tissue damage following seizures or a stroke.
IDRA-21 is a potent Ampakine. Ampakines activate AMPA receptors in the brain which has been shown to worsen brain damage. Studies on rats found that IDRA-21, when administered with glutamate killed their brain neurons. This is so dangerous for people who have had seizures and strokes because these conditions excessively activate AMPA receptors, and this causes a kind of toxicity in the brain.
Another study found that the dosages of IDRA-21 that caused this neurotoxicity were significantly higher than the doses needed to boost cognition, so researchers concluded that IDRA-21 has relatively low neurotoxicity in therapeutic doses.
For this reason, it is very important to follow the recommended dosage and precautionary measures to prevent undesirable adverse side effects.
Anecdotal evidence from some users reports that it can cause increased anxiety, hypomania, manic episodes, headaches, rapid sweating, insomnia and depression symptoms. These side effects may occur some weeks and months after you have taken the supplement.
Some users reported that this downside had put them off from trying the supplement again. You can avoid the risk of side effects by taking a small amount the first time you take it, to see how your body reacts. Also, don’t use it long term, as this increases the risk of adverse side effects. If you are at all concerned about the possibility of side effects with a relatively unknown supplement, try other nootropics that are backed up by research.